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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DENND5B
All Species:
18.48
Human Site:
Y176
Identified Species:
58.1
UniProt:
Q6ZUT9
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZUT9
NP_659410.3
1274
145020
Y176
S
L
L
K
L
Q
R
Y
N
S
Y
D
I
S
R
Chimpanzee
Pan troglodytes
XP_001138253
1296
147416
Y198
S
L
L
K
L
Q
R
Y
N
S
Y
D
I
S
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534846
1411
160944
Y313
S
L
L
K
L
Q
R
Y
N
S
Y
D
I
S
R
Cat
Felis silvestris
Mouse
Mus musculus
A2RSQ0
1274
144611
Y176
S
L
L
K
L
Q
R
Y
N
S
Y
D
I
N
R
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001235265
1482
166462
Y384
S
L
A
K
L
Q
R
Y
N
S
Y
D
I
S
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NXD8
1311
147682
V190
L
S
S
S
L
D
D
V
D
S
P
S
A
H
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395592
1282
146285
S173
H
F
K
L
S
A
H
S
P
S
A
A
L
G
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781573
1628
184518
V199
I
F
N
V
L
Y
D
V
P
L
P
P
M
G
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
N.A.
86.6
N.A.
95.3
N.A.
N.A.
N.A.
79.4
N.A.
73
N.A.
N.A.
45.5
N.A.
35.5
Protein Similarity:
100
98.3
N.A.
88.5
N.A.
97.4
N.A.
N.A.
N.A.
83.1
N.A.
83.4
N.A.
N.A.
64.1
N.A.
49.9
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
N.A.
N.A.
N.A.
93.3
N.A.
13.3
N.A.
N.A.
6.6
N.A.
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
N.A.
93.3
N.A.
20
N.A.
N.A.
13.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
0
0
13
0
0
0
0
13
13
13
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
13
25
0
13
0
0
63
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
25
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
25
13
% G
% His:
13
0
0
0
0
0
13
0
0
0
0
0
0
13
0
% H
% Ile:
13
0
0
0
0
0
0
0
0
0
0
0
63
0
0
% I
% Lys:
0
0
13
63
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
13
63
50
13
88
0
0
0
0
13
0
0
13
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
0
% M
% Asn:
0
0
13
0
0
0
0
0
63
0
0
0
0
13
0
% N
% Pro:
0
0
0
0
0
0
0
0
25
0
25
13
0
0
0
% P
% Gln:
0
0
0
0
0
63
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
63
0
0
0
0
0
0
0
75
% R
% Ser:
63
13
13
13
13
0
0
13
0
88
0
13
0
50
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
13
0
0
0
25
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
13
0
63
0
0
63
0
0
0
13
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _